Increased Wnt Signaling during Aging Alters Muscle Stem Cell Fate and Increases Fibrosis
Increased Wnt Signaling during Aging Alters Muscle Stem Cell Fate and Increases Fibrosis
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Washington, DC: American Association for the Advancement of Science
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Language
English
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Publisher
Washington, DC: American Association for the Advancement of Science
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Contents
The regenerative potential of skeletal muscle declines with age, and this impairment is associated with an increase in tissue fibrosis. We show that muscle stem cells (satellite cells) from aged mice tend to convert from a myogenic to a fibrogenic lineage as they begin to proliferate and that this conversion is mediated by factors in the systemic e...
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Full title
Increased Wnt Signaling during Aging Alters Muscle Stem Cell Fate and Increases Fibrosis
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TN_cdi_proquest_miscellaneous_68152434
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_68152434
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ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.1144090
