Highly efficient somatic-mutation identification using Escherichia coli mismatch-repair detection
Highly efficient somatic-mutation identification using Escherichia coli mismatch-repair detection
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Author / Creator
Peters, Brock A , Kan, Zhengyan , Sebisanovic, Dragan , Pujara, Kanan , Wang, Zhiyong , Hong, Peter , Chow, Bernard , Stinson, Jeremy , Carlton, Victoria E H , Pham, Thinh Q , Stern, Howard , Waring, Paul , Hillan, Kenneth J , Eberhard, David A , de Sauvage, Frederic , Zheng, Jianbiao , Faham, Malek and Seshagiri, Somasekar
Publisher
New York: Nature Publishing Group US
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English
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Publisher
New York: Nature Publishing Group US
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Contents
The discovery of somatic mutations in cancer tissue is extremely laborious, time-consuming and costly. In an evaluation comparing mismatch repair detection (MRD) against Sanger sequencing for somatic-mutation detection, we found that MRD had a specificity of 96% and a sensitivity of 92%. Our results showed that MRD is a robust and cost-effective al...
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Full title
Highly efficient somatic-mutation identification using Escherichia coli mismatch-repair detection
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TN_cdi_proquest_miscellaneous_68222365
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_68222365
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ISSN
1548-7091
E-ISSN
1548-7105
DOI
10.1038/nmeth1081
