Selective 2′-hydroxyl acylation analyzed by primer extension (SHAPE): quantitative RNA structure ana...
Selective 2′-hydroxyl acylation analyzed by primer extension (SHAPE): quantitative RNA structure analysis at single nucleotide resolution
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Publisher
London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Scope and Contents
Contents
Selective 2′-hydroxyl acylation analyzed by primer extension (SHAPE) interrogates local backbone flexibility in RNA at single-nucleotide resolution under diverse solution environments. Flexible RNA nucleotides preferentially sample local conformations that enhance the nucleophilic reactivity of 2′-hydroxyl groups toward electrophiles, such as N-met...
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Full title
Selective 2′-hydroxyl acylation analyzed by primer extension (SHAPE): quantitative RNA structure analysis at single nucleotide resolution
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TN_cdi_proquest_miscellaneous_68325611
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_68325611
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ISSN
1754-2189,1750-2799
E-ISSN
1750-2799
DOI
10.1038/nprot.2006.249
