p66SHC promotes T cell apoptosis by inducing mitochondrial dysfunction and impaired Ca2+ homeostasis
p66SHC promotes T cell apoptosis by inducing mitochondrial dysfunction and impaired Ca2+ homeostasis
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Author / Creator
Pellegrini, M , Finetti, F , Petronilli, V , Ulivieri, C , Giusti, F , Lupetti, P , Giorgio, M , Pelicci, P G , Bernardi, P and Baldari, C T
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
p66Shc, a redox enzyme that enhances reactive oxygen species (ROS) production by mitochondria, promotes T cell apoptosis. We have addressed the mechanisms regulating p66Shc-dependent apoptosis in T cells exposed to supraphysiological increases in [Ca
2+
]
c
. p66Shc expression resulted in profound mitochondrial dysfunction in response t...
Alternative Titles
Full title
p66SHC promotes T cell apoptosis by inducing mitochondrial dysfunction and impaired Ca2+ homeostasis
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Record Identifier
TN_cdi_proquest_miscellaneous_68421904
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_68421904
Other Identifiers
ISSN
1350-9047
E-ISSN
1476-5403
DOI
10.1038/sj.cdd.4401997
