Loss of Vac14, a regulator of the signaling lipid phosphatidylinositol 3,5-bisphosphate, results in...
Loss of Vac14, a regulator of the signaling lipid phosphatidylinositol 3,5-bisphosphate, results in neurodegeneration in mice
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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The signaling lipid, phosphatidylinositol 3,5-bisphosphate (PI(3,5)P₂), likely functions in multiple signaling pathways. Here, we report the characterization of a mouse mutant lacking Vac14, a regulator of PI(3,5)P₂ synthesis. The mutant mice exhibit massive neurodegeneration, particularly in the midbrain and in peripheral sensory neurons. Cell bod...
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Full title
Loss of Vac14, a regulator of the signaling lipid phosphatidylinositol 3,5-bisphosphate, results in neurodegeneration in mice
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TN_cdi_proquest_miscellaneous_68475387
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_68475387
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0702275104
