Molecular Basis of Alanine Discrimination in Editing Site
Molecular Basis of Alanine Discrimination in Editing Site
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Contents
AlaX is the homologue of the class II alanyl-tRNA synthetase editing domain and has been shown to exhibit autonomous editing activity against mischarged tRNAAla. Here, we present the structures of AlaX from the archaeon Pyrococcus horikoshii in apo form, complexed with zinc, and with noncognate amino acid L-serine and zinc. Together with mutational...
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Molecular Basis of Alanine Discrimination in Editing Site
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TN_cdi_proquest_miscellaneous_68490169
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_68490169
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0502119102
