Bag1 is essential for differentiation and survival of hematopoietic and neuronal cells
Bag1 is essential for differentiation and survival of hematopoietic and neuronal cells
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Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
Bag1 is a cochaperone for the heat-shock protein Hsp70 that interacts with C-Raf, B-Raf, Akt, Bcl-2, steroid hormone receptors and other proteins. Here we use targeted gene disruption in mice to show that Bag1 has an essential role in the survival of differentiating neurons and hematopoietic cells. Cells of the fetal liver and developing nervous sy...
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Full title
Bag1 is essential for differentiation and survival of hematopoietic and neuronal cells
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TN_cdi_proquest_miscellaneous_68525553
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_68525553
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ISSN
1097-6256
E-ISSN
1546-1726
DOI
10.1038/nn1524
