rAAV6-microdystrophin preserves muscle function and extends lifespan in severely dystrophic mice
rAAV6-microdystrophin preserves muscle function and extends lifespan in severely dystrophic mice
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New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Mice carrying mutations in both the dystrophin and utrophin genes die prematurely as a consequence of severe muscular dystrophy. Here, we show that intravascular administration of recombinant adeno-associated viral (rAAV) vectors carrying a microdystrophin gene restores expression of dystrophin in the respiratory, cardiac and limb musculature of th...
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Full title
rAAV6-microdystrophin preserves muscle function and extends lifespan in severely dystrophic mice
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TN_cdi_proquest_miscellaneous_68627686
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_68627686
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ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm1439
