Proinflammatory Responses in the Murine Brain after Intranasal Delivery of Cholera Toxin: Implicatio...
Proinflammatory Responses in the Murine Brain after Intranasal Delivery of Cholera Toxin: Implications for the Use of AB Toxins as Adjuvants in Intranasal Vaccines
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Publisher
Chicago, IL: The University of Chicago Press
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Language
English
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Publisher
Chicago, IL: The University of Chicago Press
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Contents
Intranasal delivery of vaccines provides an attractive alternative to parenteral delivery, but it requires appropriate mucosal adjuvants. Cholera toxin (CT) is a powerful mucosal adjuvant, but it can undergo retrograde transport to the brain via the olfactory system after intranasal delivery. We demonstrate that intranasal delivery of CT increases...
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Full title
Proinflammatory Responses in the Murine Brain after Intranasal Delivery of Cholera Toxin: Implications for the Use of AB Toxins as Adjuvants in Intranasal Vaccines
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TN_cdi_proquest_miscellaneous_68654781
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_68654781
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ISSN
0022-1899
E-ISSN
1537-6613
DOI
10.1086/491739
