Cortical 5-HT₂A Receptor Signaling Modulates Anxiety-Like Behaviors in Mice
Cortical 5-HT₂A Receptor Signaling Modulates Anxiety-Like Behaviors in Mice
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Author / Creator
Weisstaub, Noelia V , Zhou, Mingming , Lira, Alena , Lambe, Evelyn , González-Maeso, Javier , Hornung, Jean-Pierre , Sibille, Etienne , Underwood, Mark , Itohara, Shigeyoshi , Dauer, William T , Ansorge, Mark S , Morelli, Emanuela , Mann, J. John , Toth, Miklos , Aghajanian, George , Sealfon, Stuart C , Hen, René and Gingrich, Jay A
Publisher
Washington, DC: American Association for the Advancement of Science
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English
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Washington, DC: American Association for the Advancement of Science
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Serotonin [5-hydroxytryptamine (5-HT)] neurotransmission in the central nervous system modulates depression and anxiety-related behaviors in humans and rodents, but the responsible downstream receptors remain poorly understood. We demonstrate that global disruption of 5-HT2A receptor (5HT2AR) signaling in mice reduces inhibition in conflict anxiety...
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Cortical 5-HT₂A Receptor Signaling Modulates Anxiety-Like Behaviors in Mice
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TN_cdi_proquest_miscellaneous_68687042
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_68687042
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ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.1123432
