PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression
PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression
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Author / Creator
Day, Cheryl L. , Kaufmann, Daniel E. , Kiepiela, Photini , Brown, Julia A. , Moodley, Eshia S. , Reddy, Sharon , Mackey, Elizabeth W. , Miller, Joseph D. , Leslie, Alasdair J. , DePierres, Chantal , Mncube, Zenele , Duraiswamy, Jaikumar , Zhu, Baogong , Eichbaum, Quentin , Altfeld, Marcus , Wherry, E. John , Coovadia, Hoosen M. , Goulder, Philip J. R. , Klenerman, Paul , Ahmed, Rafi , Freeman, Gordon J. and Walker, Bruce D.
Publisher
London: Nature Publishing Group UK
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Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
HIV and immunity
Blocking a protein called PD-1 (programmed death 1) might provide a way to boost the immune function of T cells crippled by HIV infection. A study published earlier this year showed that blocking of PD-1 function in virally infected mice could restore the function of exhausted T cells and help fight infection. Now the phenomenon...
Alternative Titles
Full title
PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression
Authors, Artists and Contributors
Author / Creator
Kaufmann, Daniel E.
Kiepiela, Photini
Brown, Julia A.
Moodley, Eshia S.
Reddy, Sharon
Mackey, Elizabeth W.
Miller, Joseph D.
Leslie, Alasdair J.
DePierres, Chantal
Mncube, Zenele
Duraiswamy, Jaikumar
Zhu, Baogong
Eichbaum, Quentin
Altfeld, Marcus
Wherry, E. John
Coovadia, Hoosen M.
Goulder, Philip J. R.
Klenerman, Paul
Ahmed, Rafi
Freeman, Gordon J.
Walker, Bruce D.
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Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_68875610
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_68875610
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687,1476-4679
DOI
10.1038/nature05115
