Topoisomerase I inhibitors: camptothecins and beyond
Topoisomerase I inhibitors: camptothecins and beyond
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London: Nature Publishing Group UK
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English
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Publisher
London: Nature Publishing Group UK
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Key Points
Topoisomerase I (TOP1) enzymes are essential in higher eukaryotes, as they are required to relax DNA supercoiling generated by transcription, replication and chromatin remodelling.
Topoisomerases are particularly vulnerable to topoisomerase I inhibitors during their cleavage reaction, which is referred to as the 'cleavage complex'....
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Full title
Topoisomerase I inhibitors: camptothecins and beyond
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TN_cdi_proquest_miscellaneous_68884922
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_68884922
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ISSN
1474-175X
E-ISSN
1474-1768
DOI
10.1038/nrc1977
