Hypomethylation-linked activation of PAX2 mediates tamoxifen-stimulated endometrial carcinogenesis
Hypomethylation-linked activation of PAX2 mediates tamoxifen-stimulated endometrial carcinogenesis
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Author / Creator
Wu, Huijian , Chen, Yupeng , Liang, Jing , Shi, Bin , Wu, Ge , Zhang, Ying , Wang, Dan , Li, Ruifang , Yi, Xia , Zhang, Hua , Sun, Luyang and Shang, Yongfeng
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Tamoxifen, a selective oestrogen receptor modulator, has been used in the treatment of all stages of hormone-responsive breast cancer. However, tamoxifen shows partial oestrogenic activity in the uterus and its use has been associated with an increased incidence of endometrial cancer. The molecular explanation for these observations is not known. H...
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Full title
Hypomethylation-linked activation of PAX2 mediates tamoxifen-stimulated endometrial carcinogenesis
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TN_cdi_proquest_miscellaneous_68893549
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_68893549
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ISSN
0028-0836,1476-4687
E-ISSN
1476-4687,1476-4679
DOI
10.1038/nature04225
