Granzyme K cleaves the nucleosome assembly protein SET to induce single-stranded DNA nicks of target...
Granzyme K cleaves the nucleosome assembly protein SET to induce single-stranded DNA nicks of target cells
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Although granzymes (Gzms) A- and B-induced cell death pathways have been defined, little is known about how other orphan Gzms function in CTL-mediated cytotoxicity. GzmK and A are tryptases among all the Gzms of humans and they are closely linked on the same chromosome. In this study, we showed that GzmK can be efficiently delivered into target cel...
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Full title
Granzyme K cleaves the nucleosome assembly protein SET to induce single-stranded DNA nicks of target cells
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TN_cdi_proquest_miscellaneous_69009178
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_69009178
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ISSN
1350-9047
E-ISSN
1476-5403
DOI
10.1038/sj.cdd.4402040
