pH gating of ROMK (K(ir)1.1) channels: control by an Arg-Lys-Arg triad disrupted in antenatal Bartte...
pH gating of ROMK (K(ir)1.1) channels: control by an Arg-Lys-Arg triad disrupted in antenatal Bartter syndrome
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Author / Creator
Schulte, U , Hahn, H , Konrad, M , Jeck, N , Derst, C , Wild, K , Weidemann, S , Ruppersberg, J P , Fakler, B and Ludwig, J
Publisher
United States
Journal title
Language
English
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Publisher
United States
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Contents
Inward-rectifier K(+) channels of the ROMK (K(ir)1.1) subtype are responsible for K(+) secretion and control of NaCl absorption in the kidney. A hallmark of these channels is their gating by intracellular pH in the neutral range. Here we show that a lysine residue close to TM1, identified previously as a structural element required for pH-induced g...
Alternative Titles
Full title
pH gating of ROMK (K(ir)1.1) channels: control by an Arg-Lys-Arg triad disrupted in antenatal Bartter syndrome
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Record Identifier
TN_cdi_proquest_miscellaneous_69381402
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_69381402
Other Identifiers
ISSN
0027-8424
DOI
10.1073/pnas.96.26.15298
