Structural basis for specific cleavage of Lys 63-linked polyubiquitin chains
Structural basis for specific cleavage of Lys 63-linked polyubiquitin chains
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Deubiquitinating enzymes (DUBs) remove ubiquitin from conjugated substrates to regulate various cellular processes. The Zn
2+
-dependent DUBs AMSH and AMSH-LP regulate receptor trafficking by specifically cleaving Lys 63-linked polyubiquitin chains from internalized receptors. Here we report the crystal structures of the human AMSH-LP DUB dom...
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Full title
Structural basis for specific cleavage of Lys 63-linked polyubiquitin chains
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TN_cdi_proquest_miscellaneous_69580673
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_69580673
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ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature07254
