Poly(ADP-Ribose) Polymerase Gene Disruption Conferred Mice Resistant to Streptozotocin-Induced Diabe...
Poly(ADP-Ribose) Polymerase Gene Disruption Conferred Mice Resistant to Streptozotocin-Induced Diabetes
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Publisher
United States: National Academy of Sciences of the United States of America
Journal title
Language
English
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Publisher
United States: National Academy of Sciences of the United States of America
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Scope and Contents
Contents
Streptozotocin (STZ), a glucose analogue known to induce diabetes in experimental animals, causes DNA strand breaks and subsequent activation of poly(ADP-ribose) polymerase (Parp). Because Parp uses NAD as a substrate, extensive DNA damage will result in reduction of cellular NAD level. In fact, STZ induces NAD depletion and cell death in isolated...
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Full title
Poly(ADP-Ribose) Polymerase Gene Disruption Conferred Mice Resistant to Streptozotocin-Induced Diabetes
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TN_cdi_proquest_miscellaneous_69601116
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_69601116
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.96.5.2301
