Camptothecin analogs with enhanced activity against human breast cancer cells. II. Impact of the tum...
Camptothecin analogs with enhanced activity against human breast cancer cells. II. Impact of the tumor pH gradient
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Publisher
Berlin: Springer
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Language
English
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Publisher
Berlin: Springer
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Human breast tumors often exist in an acidic and hypoxic microenvironment, which can promote resistance to radiation and chemotherapies. A tumor-selective pH gradient arises in these tumors which favors uptake and retention of drugs like camptothecin that are weak acids. We evaluated the effect of alkyl substitutions at the 7 position in seven CPTs...
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Full title
Camptothecin analogs with enhanced activity against human breast cancer cells. II. Impact of the tumor pH gradient
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TN_cdi_proquest_miscellaneous_70191606
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_70191606
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ISSN
0344-5704
E-ISSN
1432-0843
DOI
10.1007/s00280-005-0008-5
