Switching constant domains enhances agonist activities of antibodies to a thrombopoietin receptor
Switching constant domains enhances agonist activities of antibodies to a thrombopoietin receptor
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New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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We enhanced the activities of two agonist antibodies specific for the thrombopoietin receptor (c-MPL) by switching domains within their constant regions to those of different antibody isotypes. Our results suggest the importance of the hinge region in modulating agonist activity. The antibodies' thrombopoietin-like activity
in vitro
and
in...
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Full title
Switching constant domains enhances agonist activities of antibodies to a thrombopoietin receptor
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TN_cdi_proquest_miscellaneous_70285418
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_70285418
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ISSN
1087-0156
E-ISSN
1546-1696
DOI
10.1038/nbt1376
