Remodeling of Ryanodine Receptor Complex Causes "Leaky" Channels: A Molecular Mechanism for Decrease...
Remodeling of Ryanodine Receptor Complex Causes "Leaky" Channels: A Molecular Mechanism for Decreased Exercise Capacity
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United States: National Academy of Sciences
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English
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United States: National Academy of Sciences
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During exercise, defects in calcium (Ca²⁺) release have been proposed to impair muscle function. Here, we show that during exercise in mice and humans, the major Ca²⁺ release channel required for excitation-contraction coupling (ECC) in skeletal muscle, the ryanodine receptor (RyR1), is progressively PKA-hyperphosphorylated, S-nitrosylated, and dep...
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Remodeling of Ryanodine Receptor Complex Causes "Leaky" Channels: A Molecular Mechanism for Decreased Exercise Capacity
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TN_cdi_proquest_miscellaneous_70294019
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_70294019
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0711074105
