Pharmacotherapy for cognitive impairment in a mouse model of Down syndrome
Pharmacotherapy for cognitive impairment in a mouse model of Down syndrome
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New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
Ts65Dn mice, a model for Down syndrome, have excessive inhibition in the dentate gyrus, a condition that could compromise synaptic plasticity and mnemonic processing. We show that chronic systemic treatment of these mice with GABA
A
antagonists at non-epileptic doses causes a persistent post-drug recovery of cognition and long-term potentiati...
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Full title
Pharmacotherapy for cognitive impairment in a mouse model of Down syndrome
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TN_cdi_proquest_miscellaneous_70321783
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_70321783
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ISSN
1097-6256
E-ISSN
1546-1726
DOI
10.1038/nn1860
