Preclinical Evidence that Sildenafil and Vardenafil Activate Chloride Transport in Cystic Fibrosis
Preclinical Evidence that Sildenafil and Vardenafil Activate Chloride Transport in Cystic Fibrosis
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Publisher
New York, NY: Am Thoracic Soc
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Language
English
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Publisher
New York, NY: Am Thoracic Soc
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Contents
Sildenafil has been implicated in the activation of cystic fibrosis transmembrane conductance regulator (CFTR) protein. The effect was observed in vitro and in the presence of doses roughly 300 times larger than those commonly used for treating erectile dysfunction.
To evaluate in vivo the therapeutic efficacy of clinical doses of sildenafil and...
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Full title
Preclinical Evidence that Sildenafil and Vardenafil Activate Chloride Transport in Cystic Fibrosis
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TN_cdi_proquest_miscellaneous_70324917
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_70324917
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ISSN
1073-449X
E-ISSN
1535-4970
DOI
10.1164/rccm.200703-344OC
