A novel p53 rescue compound induces p53-dependent growth arrest and sensitises glioma cells to Apo2L...
A novel p53 rescue compound induces p53-dependent growth arrest and sensitises glioma cells to Apo2L/TRAIL-induced apoptosis
About this item
Full title
Author / Creator
Weinmann, L , Wischhusen, J , Demma, M J , Naumann, U , Roth, P , DasMahapatra, B and Weller, M
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Reactivation of mutant p53 in tumours is a promising strategy for cancer therapy. Here we characterise the novel p53 rescue compound P53R3 that restores sequence-specific DNA binding of the endogenously expressed p53
R175H
and p53
R273H
mutants in gel-shift assays. Overexpression of the paradigmatic p53 mutants p53
R175H
, p53
...
Alternative Titles
Full title
A novel p53 rescue compound induces p53-dependent growth arrest and sensitises glioma cells to Apo2L/TRAIL-induced apoptosis
Authors, Artists and Contributors
Author / Creator
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_70400517
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_70400517
Other Identifiers
ISSN
1350-9047
E-ISSN
1476-5403
DOI
10.1038/sj.cdd.4402301
