Chromosomal instability by β-catenin/TCF transcription in APC or β-catenin mutant cells
Chromosomal instability by β-catenin/TCF transcription in APC or β-catenin mutant cells
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Author / Creator
Aoki, K , Aoki, M , Sugai, M , Harada, N , Miyoshi, H , Tsukamoto, T , Mizoshita, T , Tatematsu, M , Seno, H , Chiba, T , Oshima, M , Hsieh, C-L and Taketo, M M
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Adenomatous polyposis coli
(
APC/Apc
) gene encodes a key tumor suppressor whose mutations activate
β
-catenin/T-cell factor (TCF)-mediated transcription (canonical Wnt signaling). Here, we show that Wnt signaling can cause chromosomal instability (CIN). As an indicator of CIN, we scored anaphase bridge index (ABI) in mouse polyps an...
Alternative Titles
Full title
Chromosomal instability by β-catenin/TCF transcription in APC or β-catenin mutant cells
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Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_70529430
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_70529430
Other Identifiers
ISSN
0950-9232
E-ISSN
1476-5594
DOI
10.1038/sj.onc.1210141
