Mutation analysis of candidate genes within the 2q33.3 linkage area for familial early-onset general...
Mutation analysis of candidate genes within the 2q33.3 linkage area for familial early-onset generalised osteoarthritis
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Cham: Springer International Publishing
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English
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Cham: Springer International Publishing
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In a genome-wide linkage scan of seven families with familial early-onset osteoarthritis (FOA), we mapped a FOA locus to a 5 cM region on chromosome 2q33.3–2q34 with a maximum LOD score of 6.05. To identify causal variants, 17 positional candidate genes and
FRZB
were sequenced for coding, splice sites, and 5′ and 3′ untranslated regions. The...
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Full title
Mutation analysis of candidate genes within the 2q33.3 linkage area for familial early-onset generalised osteoarthritis
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TN_cdi_proquest_miscellaneous_70653155
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_70653155
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ISSN
1018-4813
E-ISSN
1476-5438
DOI
10.1038/sj.ejhg.5201829
