Thrombin and Prothrombin Are Expressed by Neurons and Glial Cells and Accumulate in Neurofibrillary...
Thrombin and Prothrombin Are Expressed by Neurons and Glial Cells and Accumulate in Neurofibrillary Tangles in Alzheimer Disease Brain
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Hagerstown, MD: American Association of Neuropathologists, Inc
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English
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Hagerstown, MD: American Association of Neuropathologists, Inc
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ABSTRACTThrombin is a serine protease that is generated by proteolytic cleavage of its precursor, prothrombin. We previously showed that thrombin proteolyses the microtubule-associated protein tau and that phosphorylation of tau inhibits this process. To characterize further the role of thrombin in the brain, we investigated prothrombin and thrombi...
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Full title
Thrombin and Prothrombin Are Expressed by Neurons and Glial Cells and Accumulate in Neurofibrillary Tangles in Alzheimer Disease Brain
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TN_cdi_proquest_miscellaneous_70676608
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_70676608
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ISSN
0022-3069
E-ISSN
1554-6578
DOI
10.1097/01.jnen.0000196133.74087.cb
