The role of seladin-1/DHCR24 in cholesterol biosynthesis, APP processing and Abeta generation in viv...
The role of seladin-1/DHCR24 in cholesterol biosynthesis, APP processing and Abeta generation in vivo
About this item
Full title
The role of seladin-1/DHCR24 in cholesterol biosynthesis, APP processing and Abeta generation in vivo
Author / Creator
Publisher
England
Journal title
The EMBO journal, 2006-01, Vol.25 (2), p.432-443
Language
English
Formats
Publication information
Publisher
England
Subjects
More information
Scope and Contents
Contents
The cholesterol-synthesizing enzyme seladin-1, encoded by the Dhcr24 gene, is a flavin adenine dinucleotide-dependent oxidoreductase and regulates responses to oncogenic and oxidative stimuli. It has a role in neuroprotection and is downregulated in affected neurons in Alzheimer's disease (AD). Here we show that seladin-1-deficient mouse brains had...
Alternative Titles
Full title
The role of seladin-1/DHCR24 in cholesterol biosynthesis, APP processing and Abeta generation in vivo
Authors, Artists and Contributors
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Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_70712100
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_70712100
Other Identifiers
ISSN
0261-4189
