DNA polymerase η is an A-T mutator in somatic hypermutation of immunoglobulin variable genes
DNA polymerase η is an A-T mutator in somatic hypermutation of immunoglobulin variable genes
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New York: Nature Publishing Group US
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English
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New York: Nature Publishing Group US
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To determine whether DNA polymerase η plays a role in the hypermutation of immunoglobulin variable genes, we examined the frequency and pattern of substitutions in variable V
H
6 genes from the peripheral blood lymphocytes of three patients with xeroderma pigmentosum variant disease, whose polymerase η had genetic defects. The frequency of mu...
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Full title
DNA polymerase η is an A-T mutator in somatic hypermutation of immunoglobulin variable genes
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TN_cdi_proquest_miscellaneous_70873852
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_70873852
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ISSN
1529-2908
E-ISSN
1529-2916
DOI
10.1038/88740
