Mechanisms of inactivation of E-cadherin in breast carcinoma: modification of the two-hit hypothesis...
Mechanisms of inactivation of E-cadherin in breast carcinoma: modification of the two-hit hypothesis of tumor suppressor gene
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Basingstoke: Nature Publishing
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English
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Basingstoke: Nature Publishing
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Loss of heterozygosity (LOH) allows the expression of recessive mutation in tumor suppressor genes (TSG). Therefore, on the basis of Knudson's 'two-hit' hypothesis for TSG inactivation, the detection of a high LOH frequency in a chromosomal region is considered critical for TSG localization. One of these LOH regions in breast cancer is 16q22.1, whi...
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Mechanisms of inactivation of E-cadherin in breast carcinoma: modification of the two-hit hypothesis of tumor suppressor gene
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TN_cdi_proquest_miscellaneous_70982811
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_70982811
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ISSN
0950-9232
E-ISSN
1476-5594
DOI
10.1038/sj.onc.1204505
