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Structure of a novel leech carboxypeptidase inhibitor determined free in solution and in complex wit...

Structure of a novel leech carboxypeptidase inhibitor determined free in solution and in complex wit...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_70998179

Structure of a novel leech carboxypeptidase inhibitor determined free in solution and in complex with human carboxypeptidase A2

About this item

Full title

Structure of a novel leech carboxypeptidase inhibitor determined free in solution and in complex with human carboxypeptidase A2

Publisher

New York: Nature Publishing Group US

Journal title

Nature Structural Biology, 2000-04, Vol.7 (4), p.322-328

Language

English

Formats

Publication information

Publisher

New York: Nature Publishing Group US

More information

Scope and Contents

Contents

Leech carboxypeptidase inhibitor (LCI) is a novel protein inhibitor present in the medicinal leech
Hirudo medicinalis
. The structures of LCI free and bound to carboxypeptidase A2 (CPA2)have been determined by NMR and X-ray crystallography, respectively. The LCI structure defines a new protein motif that comprises a five-stranded antiparallel...

Alternative Titles

Full title

Structure of a novel leech carboxypeptidase inhibitor determined free in solution and in complex with human carboxypeptidase A2

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_miscellaneous_70998179

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_70998179

Other Identifiers

ISSN

1072-8368,1545-9993

E-ISSN

1545-9985

DOI

10.1038/74092

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