Disruption of BRCA1 LXCXE motif alters BRCA1 functional activity and regulation of RB family but not...
Disruption of BRCA1 LXCXE motif alters BRCA1 functional activity and regulation of RB family but not RB protein binding
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Basingstoke: Nature Publishing
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English
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Basingstoke: Nature Publishing
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The tumor suppressor activity of the BRCA1 gene product is due, in part, to functional interactions with other tumor suppressors, including p53 and the retinoblastoma (RB) protein. RB binding sites on BRCA1 were identified in the C-terminal BRCT domain (Yarden and Brody, 1999) and in the N-terminus (aa 304-394) (Aprelikova et al., 1999). The N-term...
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Full title
Disruption of BRCA1 LXCXE motif alters BRCA1 functional activity and regulation of RB family but not RB protein binding
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TN_cdi_proquest_miscellaneous_71118711
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_71118711
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ISSN
0950-9232
E-ISSN
1476-5594
DOI
10.1038/sj.onc.1204666
