Acceleration of intestinal polyposis through prostaglandin receptor EP2 in Apc(Delta 716) knockout m...
Acceleration of intestinal polyposis through prostaglandin receptor EP2 in Apc(Delta 716) knockout mice
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Author / Creator
Sonoshita, M , Takaku, K , Sasaki, N , Sugimoto, Y , Ushikubi, F , Narumiya, S , Oshima, M and Taketo, M M
Publisher
United States
Journal title
Language
English
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Publisher
United States
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Contents
Arachidonic acid is metabolized to prostaglandin H(2) (PGH(2)) by cyclooxygenase (COX). COX-2, the inducible COX isozyme, has a key role in intestinal polyposis. Among the metabolites of PGH(2), PGE(2) is implicated in tumorigenesis because its level is markedly elevated in tissues of intestinal adenoma and colon cancer. Here we show that homozygou...
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Full title
Acceleration of intestinal polyposis through prostaglandin receptor EP2 in Apc(Delta 716) knockout mice
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TN_cdi_proquest_miscellaneous_71145192
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_71145192
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ISSN
1078-8956
DOI
10.1038/nm0901-1048
