Effect of the single CYP2C93 allele on pharmacokinetics and pharmacodynamics of losartan in healthy...
Effect of the single CYP2C93 allele on pharmacokinetics and pharmacodynamics of losartan in healthy Japanese subjects
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Publisher
Heidelberg: Springer
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Language
English
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Heidelberg: Springer
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Losartan is metabolized to the active carboxylic acid metabolite EXP3174 by CYP2C9. In this study, we determined the effects of the single CYP2C9*3 variant on the pharmacokinetics and pharmacodynamics of losartan.
Seven healthy Japanese subjects ( CYP2C9*1/*1, n=4 and CYP2C9*1/*3, n=3) were phenotyped with a single dose of losartan (25 mg). Bloo...
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Full title
Effect of the single CYP2C93 allele on pharmacokinetics and pharmacodynamics of losartan in healthy Japanese subjects
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TN_cdi_proquest_miscellaneous_71359641
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_71359641
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ISSN
0031-6970
E-ISSN
1432-1041
DOI
10.1007/s00228-003-0664-5
