HIV protease inhibitors are potent anti-angiogenic molecules and promote regression of Kaposi sarcom...
HIV protease inhibitors are potent anti-angiogenic molecules and promote regression of Kaposi sarcoma
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Author / Creator
Sgadari, Cecilia , Barillari, Giovanni , Toschi, Elena , Carlei, Davide , Bacigalupo, Ilaria , Baccarini, Sara , Palladino, Clelia , Leone, Patrizia , Bugarini, Roberto , Malavasi, Laura , Cafaro, Aurelio , Falchi, Mario , Valdembri, Donatella , Rezza, Giovanni , Bussolino, Federico , Monini, Paolo and Ensoli, Barbara
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publisher
New York: Nature Publishing Group US
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Scope and Contents
Contents
Treatment with HIV-1 protease inhibitors (PI) is associated with a reduced incidence or regression of Kaposi sarcoma (KS). Here we show that systemic administration of the PIs indinavir or saquinavir to nude mice blocks the development and induces regression of angioproliferative KS-like lesions promoted by primary human KS cells, basic fibroblast...
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Full title
HIV protease inhibitors are potent anti-angiogenic molecules and promote regression of Kaposi sarcoma
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Record Identifier
TN_cdi_proquest_miscellaneous_71497741
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_71497741
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ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm0302-225
