Structural characterization of a subtype-selective ligand reveals a novel mode of estrogen receptor...
Structural characterization of a subtype-selective ligand reveals a novel mode of estrogen receptor antagonism
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Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
The
R
,
R
enantiomer of 5,11-
cis
-diethyl-5,6,11,12-tetrahydrochrysene-2,8-diol (THC) exerts opposite effects on the transcriptional activity of the two estrogen receptor (ER) subtypes, ERα and ERβ. THC acts as an ERα agonist and as an ERβ antagonist. We have determined the crystal structures of the ERα ligand binding domain (LBD...
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Full title
Structural characterization of a subtype-selective ligand reveals a novel mode of estrogen receptor antagonism
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TN_cdi_proquest_miscellaneous_71628569
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_71628569
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ISSN
1072-8368,1545-9993
E-ISSN
1545-9985
DOI
10.1038/nsb787
