Genetic Evidence for the Bidirectional Modulation of Synaptic Plasticity in the Prefrontal Cortex by...
Genetic Evidence for the Bidirectional Modulation of Synaptic Plasticity in the Prefrontal Cortex by D1 Receptors
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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To address the role of D1 receptors in the medial prefrontal cortex, we combined pharmacological and genetic manipulations to examine long-term synaptic potentiation (LTP)/long-term synaptic depression (LTD) in brain slices of rats and mice. We found that the D1 antagonist SCH23390 selectively blocked the maintenance but not the induction of LTP in...
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Full title
Genetic Evidence for the Bidirectional Modulation of Synaptic Plasticity in the Prefrontal Cortex by D1 Receptors
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TN_cdi_proquest_miscellaneous_71703642
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_71703642
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0308280101
