The Aspartate-257 of Presenilin 1 is Indispensable for Mouse Development and Production of β-Amyloid...
The Aspartate-257 of Presenilin 1 is Indispensable for Mouse Development and Production of β-Amyloid Peptides through β-Catenin-Independent Mechanisms
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Publisher
United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Contents
To differentiate multiple activities of presenilin 1 (PS1), we generated transgenic mice expressing two human PS1 alleles: one with the aspartate to alanine mutation at residue 257 (hPS1D257A) that impairs the proteolytic activity of PS1, and the other deleting amino acids 340-371 of the hydrophilic loop sequence (hPS1Δcat) essential for β-catenin...
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Full title
The Aspartate-257 of Presenilin 1 is Indispensable for Mouse Development and Production of β-Amyloid Peptides through β-Catenin-Independent Mechanisms
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TN_cdi_proquest_miscellaneous_71852778
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_71852778
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.132045399
