High-affinity binders selected from designed ankyrin repeat protein libraries
High-affinity binders selected from designed ankyrin repeat protein libraries
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Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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We report here the evolution of ankyrin repeat (AR) proteins
in vitro
for specific, high-affinity target binding. Using a consensus design strategy, we generated combinatorial libraries of AR proteins of varying repeat numbers with diversified binding surfaces. Libraries of two and three repeats, flanked by 'capping repeats,' were used in rib...
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Full title
High-affinity binders selected from designed ankyrin repeat protein libraries
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TN_cdi_proquest_miscellaneous_71894443
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_71894443
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ISSN
1087-0156
E-ISSN
1546-1696
DOI
10.1038/nbt962
