Antagonistic antibody prevents toll-like receptor 2–driven lethal shock-like syndromes
Antagonistic antibody prevents toll-like receptor 2–driven lethal shock-like syndromes
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Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
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Publisher
United States: American Society for Clinical Investigation
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Scope and Contents
Contents
Hyperactivation of immune cells by bacterial products through toll-like receptors (TLRs) is thought of as a causative mechanism of septic shock pathology. Infections with Gram-negative or Gram-positive bacteria provide TLR2-specific agonists and are the major cause of severe sepsis. In order to intervene in TLR2-driven toxemia, we raised mAb's agai...
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Full title
Antagonistic antibody prevents toll-like receptor 2–driven lethal shock-like syndromes
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Record Identifier
TN_cdi_proquest_miscellaneous_71936548
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_71936548
Other Identifiers
ISSN
0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI20762
