UV-induction of keratinocyte endothelin-1 downregulates E-cadherin in melanocytes and melanoma cells
UV-induction of keratinocyte endothelin-1 downregulates E-cadherin in melanocytes and melanoma cells
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Publisher
United States: American Society for Clinical Investigation
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Language
English
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Publisher
United States: American Society for Clinical Investigation
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Contents
Endothelin-1 (ET-1), a peptide that is secreted by keratinocytes in the skin in response to ultraviolet irradiation, is a ligand for the endothelin-B (ET(B)) receptor. Blockade of this receptor inhibits melanoma cell growth and induces cell death in vivo and in vitro. Additionally, ET(B) is a melanoma progression marker. These findings suggest that...
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Full title
UV-induction of keratinocyte endothelin-1 downregulates E-cadherin in melanocytes and melanoma cells
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TN_cdi_proquest_miscellaneous_72019499
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_72019499
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ISSN
0021-9738
E-ISSN
1558-8238
DOI
10.1172/jci0213729
