Akt regulates growth by directly phosphorylating Tsc2
Akt regulates growth by directly phosphorylating Tsc2
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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The direct mechanism by which the serine/threonine kinase Akt (also known as protein kinase B (PKB)) regulates cell growth is unknown. Here, we report that
Drosophila melanogaster
Akt/PKB stimulates growth by phosphorylating the tuberous sclerosis complex 2 (Tsc2) tumour suppressor and inhibiting formation of a Tsc1–Tsc2 complex. We show that...
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Akt regulates growth by directly phosphorylating Tsc2
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TN_cdi_proquest_miscellaneous_72048189
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_72048189
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ISSN
1465-7392,1476-4679
E-ISSN
1476-4679
DOI
10.1038/ncb840
