Inhibition of BRCA1 leads to increased chemoresistance to microtubule-interfering agents, an effect...
Inhibition of BRCA1 leads to increased chemoresistance to microtubule-interfering agents, an effect that involves the JNK pathway
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Basingstoke: Nature Publishing
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English
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Basingstoke: Nature Publishing
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We have developed ribozymes (Rz) that inhibit BRCA1 expression in order to study the role of this gene in chemosensitivity. Two Rz, targeting positions 358 or 5282 of the BRCA1 mRNA, were cloned into the retroviral vector LXSN and lipofected into the breast cancer cell-line HBL100. We obtained 79-99% inhibition of BRCA1 expression, as determined by...
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Inhibition of BRCA1 leads to increased chemoresistance to microtubule-interfering agents, an effect that involves the JNK pathway
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TN_cdi_proquest_miscellaneous_72215765
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_72215765
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0950-9232
E-ISSN
1476-5594
DOI
10.1038/sj.onc.1204812
