Amiloride derivatives are potent blockers of KATP channels
Amiloride derivatives are potent blockers of KATP channels
About this item
Full title
Amiloride derivatives are potent blockers of KATP channels
Author / Creator
Publisher
Germany
Journal title
Naunyn-Schmiedeberg's archives of pharmacology, 2001-10, Vol.364 (4), p.351-358
Language
English
Formats
Publication information
Publisher
Germany
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More information
Scope and Contents
Contents
In cardiomyocytes sarcolemmal KATP channels open massively when the cytosolic [ATP] drops into the range of tens of micromolar, as during acute ischemia. The diuretic drug amiloride and related derivatives are well established as drugs blocking the Na+/H+- and the Na+/Ca2+-exchange, protecting the ischemic heart. Herein, the blocking action of amil...
Alternative Titles
Full title
Amiloride derivatives are potent blockers of KATP channels
Authors, Artists and Contributors
Author / Creator
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Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_72236117
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_72236117
Other Identifiers
ISSN
0028-1298
DOI
10.1007/s002100100466
