A fluorimetric enzyme assay for the diagnosis of MPS II (Hunter disease)
A fluorimetric enzyme assay for the diagnosis of MPS II (Hunter disease)
About this item
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Author / Creator
Publisher
Dordrecht: Kluwer Academic Publishers
Journal title
Language
English
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Publisher
Dordrecht: Kluwer Academic Publishers
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Scope and Contents
Contents
4‐Methylumbelliferyl‐α‐iduronate 2‐sulphate was synthesized and shown to be a specific substrate for the lysosomal iduronate‐2‐sulphate sulphatase (IDS). Fibroblasts (n = 17), leukocytes (n = 3) and plasmas (n = 9) from different MPS II patients showed <5% of mean normal IDS activity. The enzymatic liberation of the fluorochrome from 4‐methylumbell...
Alternative Titles
Full title
A fluorimetric enzyme assay for the diagnosis of MPS II (Hunter disease)
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Record Identifier
TN_cdi_proquest_miscellaneous_72370468
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_72370468
Other Identifiers
ISSN
0141-8955
E-ISSN
1573-2665
DOI
10.1023/A:1012763026526
