β cells are responsible for CXCR3-mediated T-cell infiltration in insulitis
β cells are responsible for CXCR3-mediated T-cell infiltration in insulitis
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New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
T cell–mediated loss of insulin-secreting β cells in the islets of Langerhans is the hallmark of type 1 diabetes. The molecular basis for the directed migration of autoreactive T cells leading to insulitis is presently unknown. Here we demonstrate that in response to inflammation, β cells secrete the chemokines CXC ligand 10 and CXC ligand 9, which...
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Full title
β cells are responsible for CXCR3-mediated T-cell infiltration in insulitis
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TN_cdi_proquest_miscellaneous_72718796
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_72718796
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ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm1202-792
