Gain of function mutations of RTK conserved residues display differential effects on NTRK1 kinase ac...
Gain of function mutations of RTK conserved residues display differential effects on NTRK1 kinase activity
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Basingstoke: Nature Publishing
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English
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Basingstoke: Nature Publishing
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Activation of tyrosine kinase receptors is associated with human tumors. Tumorigenic versions of several RTKs, such as Ret, Kit and Met carry activating mutations at highly conserved residues of the tyrosine kinase domain. We have investigated the effect of some of these mutations on the NTRK1/NGF receptor, for which no naturally occurring activati...
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Gain of function mutations of RTK conserved residues display differential effects on NTRK1 kinase activity
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TN_cdi_proquest_miscellaneous_72727088
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_72727088
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ISSN
0950-9232
E-ISSN
1476-5594
DOI
10.1038/sj.onc.1206052
