Selective ablation of human cancer cells by telomerase-specific adenoviral suicide gene therapy vect...
Selective ablation of human cancer cells by telomerase-specific adenoviral suicide gene therapy vectors expressing bacterial nitroreductase
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London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Reactivation of telomerase maintains telomere function and is considered critical to immortalization in most human cancer cells. Elevation of telomerase expression in cancer cells is highly specific: transcription of both RNA (hTR) and protein (hTERT) components is strongly upregulated in cancer cells relative to normal cells. Therefore, telomerase...
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Selective ablation of human cancer cells by telomerase-specific adenoviral suicide gene therapy vectors expressing bacterial nitroreductase
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TN_cdi_proquest_miscellaneous_72972512
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_72972512
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ISSN
0950-9232
E-ISSN
1476-5594
DOI
10.1038/sj.onc.1206168
