Disruption of the Fanconi anemia–BRCA pathway in cisplatin-sensitive ovarian tumors
Disruption of the Fanconi anemia–BRCA pathway in cisplatin-sensitive ovarian tumors
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New York: Nature Publishing Group US
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English
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Publisher
New York: Nature Publishing Group US
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Ovarian tumor cells are often genomically unstable and hypersensitive to cisplatin. To understand the molecular basis for this phenotype, we examined the integrity of the Fanconi anemia–BRCA (FANC-BRCA) pathway in those cells. This pathway regulates cisplatin sensitivity and is governed by the coordinate activity of six genes associated with Fancon...
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Full title
Disruption of the Fanconi anemia–BRCA pathway in cisplatin-sensitive ovarian tumors
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TN_cdi_proquest_miscellaneous_73235312
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_73235312
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ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm852
