Metformin suppresses hepatic gluconeogenesis and lowers fasting blood glucose levels through reactiv...
Metformin suppresses hepatic gluconeogenesis and lowers fasting blood glucose levels through reactive nitrogen species in mice
About this item
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Author / Creator
Fujita, Y , Hosokawa, M , Fujimoto, S , Mukai, E , Abudukadier, A , Obara, A , Ogura, M , Nakamura, Y , Toyoda, K , Nagashima, K , Seino, Y and Inagaki, N
Publisher
Berlin/Heidelberg: Berlin/Heidelberg : Springer-Verlag
Journal title
Language
English
Formats
Publication information
Publisher
Berlin/Heidelberg: Berlin/Heidelberg : Springer-Verlag
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More information
Scope and Contents
Contents
Aims/hypothesis Metformin, the major target of which is liver, is commonly used to treat type 2 diabetes. Although metformin activates AMP-activated protein kinase (AMPK) in hepatocytes, the mechanism of activation is still not well known. To investigate AMPK activation by metformin in liver, we examined the role of reactive nitrogen species (RNS)...
Alternative Titles
Full title
Metformin suppresses hepatic gluconeogenesis and lowers fasting blood glucose levels through reactive nitrogen species in mice
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Record Identifier
TN_cdi_proquest_miscellaneous_733091629
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_733091629
Other Identifiers
ISSN
0012-186X
E-ISSN
1432-0428
DOI
10.1007/s00125-010-1729-5
