Activated polyamine catabolism leads to low cholesterol levels by enhancing bile acid synthesis
Activated polyamine catabolism leads to low cholesterol levels by enhancing bile acid synthesis
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Publisher
Vienna: Vienna : Springer Vienna
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Language
English
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Publisher
Vienna: Vienna : Springer Vienna
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Scope and Contents
Contents
Transgenic mice with activated polyamine catabolism due to overexpression of spermidine/spermine N¹-acetyltransferase (SSAT) have significantly reduced plasma total cholesterol levels. In our study, we show that low cholesterol levels were attributable to enhanced bile acid synthesis in combination with reduced cholesterol absorption. Hepatic chole...
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Full title
Activated polyamine catabolism leads to low cholesterol levels by enhancing bile acid synthesis
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TN_cdi_proquest_miscellaneous_733119624
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_733119624
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ISSN
0939-4451
E-ISSN
1438-2199
DOI
10.1007/s00726-009-0416-7
